Pharmacological effects
1. [Antibacterial action]: In vitro bacteriostasis test (paper method, each paper containing crude drug amount of about 30mg) is applied to the extinguishment test of Diclodia Injection (water decoction-concentrated alcohol extract, followed by addition of lead acetate to remove precipitate). Staphylococcus aureus and E. coli have bacteriostatic action. When the plate-pour method is used, each 15 ml contains 18-24 g of crude drug, and it also has antibacterial effect against Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella and Staphylococcus aureus.
2. [anti-inflammatory]: decoction 10g/kg gavage, inhibition of rat egg white arthritis; ethanol formulation 5g/kg gavage, formaldehyde arthritis also inhibited.
3. [Antitumor]: Dibiluronolide and diterpenoid lactone have cytotoxic activity on KB cells in vivo and in vitro, and bilbolactone has a significant inhibitory effect on mouse leukemia P388; The esters and diterpenoid lactones were 50-100 mg/kg, respectively, and had a significant inhibitory effect on -256 of WACKER sarcoma in rats. The half-effective inhibition concentration of human nasopharyngeal carcinoma-KB cells was 0.28-2.0 μg in vitro. /ml; deoxygenation of diterpenoid lactone on the rat WACKER tumor -256 also significantly inhibited.
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