Tacrolimus CAS: 104987-11-3

Product Name:Tacrolimus
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Melting point: 113-115°C
Fp: 2ºC
Storage temp.: −20°C
Chemical Properties: White Crystalline Solid

Uses: 

For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart.

Tacrolimus Powder Description:
1.Tacrolimus is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
 
2.A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
 
3.Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
 
4.Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
 
5.Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, basiliximab, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

6.Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.
 
Tacrolimus Powder Mechanism of action:
1.The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
 
2.A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
 
3.Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.
 
Tacrolimus Powder Usages:
1.Tacroz Forte Ointment (Tacrolimus) is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
 
2.The ointment is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.

Dermatological use:
1.As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
2.It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face

Tacrolimus Powder Dosage and Administration:
Tacroz Forte Ointment (Tacrolimus) is applied directly to the affected skin. Patients are normally advised to apply the ointment twice a day for a period of approximately 6 weeks in length. If no changes or improvements to your condition occur after this period, consult your physician to discuss how best to go forward.

COA:

Popular Pharmaceutical raw materials We Recommend:
 

Local Anesthetic Agents We offer

Our advantage:

1. Rich experience.

Our company is a professional manufacturer leading in China in pharmaceutical area .We specialize in this field for 19 years. Our steroids and pharmaceutical raw materials have been exported to the whole world.We have got very good feedback from our customers, and established long friendly relations of cooperation.

2. Great quality, purity and favorable.

Our products are after repeated extraction, multiple detection,good quality is one secret for our success. Welcome order the samples, MOQ just 10 grams.

3. Safest and fastest delivery.

Safe and professional disguised package can be guaranteed.We have adequate stock, we can arrange the delivery within 24hours when receiving the payment.

Tracking number would be informed quickly after shipment.

We have special way which could ship 0.01 kilo to 50 kilo products a time.Provide door-to-door delivery.

4. Good after-sales service.

24/7 is available. Tell the package update info ASAP. And try our best to solve various problems customers encounter timely!

5. Experiential shopping

Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how to make hormone solution on the site.

We also provide semi-finished products, only need to filter by yourself, can be used as a finished product.

 

 

 

Delivery terms:

Minimum Order Quantity:10g

Delivery time or FOB:within 3-6 days after payment

Storage: Shading, Confined Preservation

Payment options:Western Union,Money Gram,T/T,Bitcoin

Package:Exquisite,Camouflage according to your requirement

Shipping leading time:Within 12 hours after receiving the payment.

Shipping:Express delivery with HKEMS,DHL,FedEX,EMS etc
 

Order Guide:

Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Bitcoin or  Moneygram
 
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the up most care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should 
undertake by your side.
 
As a leading manufacturer of steroid raw materials and  Peptides 
We specialized in manufacturing high quality and reliable raw material 
which are widely used in the fields of food, health, cosmetics, pharmaceuticals, and Bodybuilding
 
we have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .

Product Name:Tacrolimus
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Melting point: 113-115°C
Fp: 2ºC
Storage temp.: −20°C
Chemical Properties: White Crystalline Solid

Uses: 

For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart.

Tacrolimus Powder Description:
1.Tacrolimus is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
 
2.A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
 
3.Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
 
4.Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
 
5.Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, basiliximab, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

6.Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.
 
Tacrolimus Powder Mechanism of action:
1.The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
 
2.A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
 
3.Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.
 
Tacrolimus Powder Usages:
1.Tacroz Forte Ointment (Tacrolimus) is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
 
2.The ointment is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.

Dermatological use:
1.As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
 
2.It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face

Tacrolimus Powder Dosage and Administration:
Tacroz Forte Ointment (Tacrolimus) is applied directly to the affected skin. Patients are normally advised to apply the ointment twice a day for a period of approximately 6 weeks in length. If no changes or improvements to your condition occur after this period, consult your physician to discuss how best to go forward.

COA:

Popular Pharmaceutical raw materials We Recommend:
 

Local Anesthetic Agents We offer

Our advantage:

1. Rich experience.

Our company is a professional manufacturer leading in China in pharmaceutical area .We specialize in this field for 19 years. Our steroids and pharmaceutical raw materials have been exported to the whole world.We have got very good feedback from our customers, and established long friendly relations of cooperation.

2. Great quality, purity and favorable.

Our products are after repeated extraction, multiple detection,good quality is one secret for our success. Welcome order the samples, MOQ just 10 grams.

3. Safest and fastest delivery.

Safe and professional disguised package can be guaranteed.We have adequate stock, we can arrange the delivery within 24hours when receiving the payment.

Tracking number would be informed quickly after shipment.

We have special way which could ship 0.01 kilo to 50 kilo products a time.Provide door-to-door delivery.

4. Good after-sales service.

24/7 is available. Tell the package update info ASAP. And try our best to solve various problems customers encounter timely!

5. Experiential shopping

Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how to make hormone solution on the site.

We also provide semi-finished products, only need to filter by yourself, can be used as a finished product.

 

 

 

Delivery terms:

Minimum Order Quantity:10g

Delivery time or FOB:within 3-6 days after payment

Storage: Shading, Confined Preservation

Payment options:Western Union,Money Gram,T/T,Bitcoin

Package:Exquisite,Camouflage according to your requirement

Shipping leading time:Within 12 hours after receiving the payment.

Shipping:Express delivery with HKEMS,DHL,FedEX,EMS etc
 

Order Guide:

Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Bitcoin or  Moneygram
 
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the up most care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should 
undertake by your side.
 
As a leading manufacturer of steroid raw materials and  Peptides 
We specialized in manufacturing high quality and reliable raw material 
which are widely used in the fields of food, health, cosmetics, pharmaceuticals, and Bodybuilding
 
we have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .